Hypotensive Activity of Ethanolic Extracts of Morinda citrifolia L. Leaves and Fruit in Dexamethasone-Induced Hypertensive Rat

Anwar, Khoerul Hypotensive Activity of Ethanolic Extracts of Morinda citrifolia L. Leaves and Fruit in Dexamethasone-Induced Hypertensive Rat. Journal of Evidence-Based Complementary & Alternative Medicine. ISSN DOI: 10.1177/2156587216653660

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Official URL: http://journals.sagepub.com/doi/full/10.1177/21565...

Abstract

Abstract The effect of ethanolic extract of Morinda citrifolia leaves and fruit on blood pressure in dexamethasone-induced hypertension rat was evaluated. Total phenolic content of Morinda citrifolia leaves ethanolic extract (MCLEE) and Morinda citrifolia leaves ethanolic extract (MCFEE) was 1.789+0.116 and 1.677+0.051 mg of gallic acid equivalents per gram sample, respectively. Rutin level in MCLEE was 0.92 + 0.19%, and scopoletin level in MCFEE was 0.46 + 0.05%. MCLEE, MCFEE, and its extract combination significantly decreased the blood pressure of hypertensive rats. The combination group showed highest hypotensive activity by lowering systolic blood pressure by 16.71+3.95%, diastolic blood pressure by 21.49+7.90%, and mean arterial blood pressure by 19.58% + 6.35. All extract treatments have not been able to repair or inhibit renal damage caused by dexamethasone induction.

Item Type: Article
Subjects: A General Works > AI Indexes (General)
Depositing User: Mr Arief Mirathan
Date Deposited: 13 Mar 2018 05:06
Last Modified: 13 Mar 2018 05:06
URI: http://eprints.ulm.ac.id/id/eprint/3045

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