HEPATOPROTECTIVE EFFECT OF Leucosyke capitellata Wedd. (KAJAJAHI) LEAVES AGAINST CCl4-INDUCED LIVER DAMAGE IN MICE

Nurlely, Nurlely HEPATOPROTECTIVE EFFECT OF Leucosyke capitellata Wedd. (KAJAJAHI) LEAVES AGAINST CCl4-INDUCED LIVER DAMAGE IN MICE. HEPATOPROTECTIVE EFFECT OF Leucosyke capitellata Wedd. (KAJAJAHI) LEAVES AGAINST CCl4-INDUCED LIVER DAMAGE IN MICE.

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Official URL: http://farmasi.unpad.ac.id/ispst2016/

Abstract

Leucosyke capitellata Wedd. (Kajajahi) has been considered as an antioxidant to relieve oxidative stress. It was triggered by excessive reactive oxygen and nitrogen species which may lead to the initiation and progression of liver damage. The aim of this study was to investigate hepaprotective effect of decoction of L. capitellata Wedd leaves using carbon tetrachloride (CCl4)-induced hepatic damage in mice. Healthy male BALB/c mice were randomly divided into six groups of 5 mice each. On day 1, all groups excluding control group were intraperitoneally induced CCl4 1.5 ml/kg bw. On day 2 until 10, control group received aquadest po, CCl4 group received Na CMC 0.5% po and reference group received silymarin at dose of 100 mg/kg bw po. For 3 decoction of L. capitellata Wedd leaves (DLC) groups received DLC at doses of 0.35, 1.75 and 3.5 g/kg bw po. On day 11, blood and liver samples were collected for biochemical (AST, ALT, TP and ALP) and liver histopathological examinations. The results revealed that DLC was able to significantly decrease ALT, AST and ALP levels (P<0.05) as well as significantly increase TP level (P<0.05). Liver histopathological examinations supported the biochemical analysis in repairing liver damage. Therefore, it can be concluded that DLC in this present study may possess hepatoprotective effect which are compared with reference drug of silymarin. Keywords: Leucosyke capitellata Wedd, biochemical analysis, liver damage

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: Mr Arief Mirathan - Eka Setya Wijaya
Date Deposited: 07 Dec 2016 01:14
Last Modified: 17 Mar 2017 03:00
URI: http://eprints.unlam.ac.id/id/eprint/1419

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